Collingwood has derailed Brisbane's chances of going back to the NAB AFL Women's Grand Final with an upset 14-point win at Burpengary on Saturday.

The 8.5 (53) to 5.9 (39) victory was the Magpies' second of the season and came on the back of a scintillating four-goal opening quarter.

Forward partners Christina Bernardi and Moana Hope kicked two goals apiece in the opening onslaught as the Pies moved the ball beautifully in the wet conditions.

The win moves them from last up into sixth position.

For the Lions the loss is a disaster as they now need to beat Greater Western Sydney in the final round and also hope Adelaide - and likely Melbourne - lose.

Collingwood led by as much as 32 points and despite three late consolation goals by the Lions, were never challenged.

The Magpies were not only the more desperate team, but the more polished.

Bernardi was brilliant, kicking three goals from her 16 disposals and seven marks.

Hope also finished with three goals while Jasmine Garner gave the vaunted Lions defence headaches with her 17 disposals, six marks and 1.3.

Chloe Molloy (16 touches) was outstanding off half-back, while Caitlyn Edwards (12 touches and 10 tackles) was in everything, particularly in the scene-setting first half.

For a team that had everything to play for, the Lions were disappointing.

"The focus was to get a fast start and the opposite happened," coach Craig Starcevich said.

"Full credit to the opposition, their skill and execution and decision making under adverse conditions was exceptional.

"Destiny's out of our hands, so now we're watching results and hoping things go your way.

"They're (players) disappointed, no doubt about it, they've let an opportunity slip."

Emily Bates (20), Jamie Stanton (18) and Ally Anderson (17) got plenty of ball in the midfield, but it was often rushed and under pressure.

BRISBANE LIONS     2.2       2.4       2.6       5.9 (39)
COLLINGWOOD        4.4       4.4       6.5       8.5 (53)

GOALS
Brisbane Lions: Frederick-Traub, Exon, Wuetschner, Lutkins, Ashmore
Collingwood: Bernardi 3, Hope 3, Garner, Hutchins

BEST 
Brisbane Lions: Lutkins, Frederick-Traub, Bates, Gibson, Stanton
Collingwood: Bernardi, Garner, Molloy, Hope, Edwards, Duffin

INJURIES 
Brisbane Lions: Nil
Collingwood: Nil

Reports: Nil

Umpires: Young, Strybos, Curtis 

Official (estimated) crowd: 2600 at South Pine Central Sports Complex (Burpengary)