The scores were locked at 63 each at the final change, and after a topsy-turvy first 20 minutes of the fourth quarter, late goals to Bradd Dalziell, Matt Rosa and one on the run from Josh Hill sealed the deal.
The scoreline did not reflect the closeness of the contest, as the Lions fought hard all day, but Michael Voss' men have now slumped to a 2-5 record with a nightmare six-match stretch ahead.
They had far more of the ball (373-308 disposals) and matched the Eagles in the hard work areas of clearances (40-43), contested possessions (154 to both teams) and tackles (70-67).
Nic Naitanui got through his first full game of the season, mixing time with his partner-in-crime Dean Cox in the ruck and up forward.
His direct opponent Matthew Leuenberger was colossal for the losing team, working tirelessly around the ground and capping his game with a terrific dribbled goal in front of Cox.
Lions coach Michael Voss named returning Brownlow medallist Simon Black as a substitute, and was almost made to look like a genius when Black finished with 12 disposals and a goal in just over a quarter.
Tom Rockliff (34), Pearce Hanley (31) and Brent Moloney were influential for the losers.
BRISBANE LIONS 3.0 6.6 9.9 12.10 (82)
WEST COAST 4.2 7.2 10.3 17.6 (108)
GOALS
Brisbane Lions: Golby 2, Bewick 2, Brown 2, Redden, Zorko, McGrath, Leuenberger, Black, Lisle
West Coast: Kennedy 4, Lecras 3, Sheppard 2, Naitanui 2, Hill 2, Shuey, Dalziell, Rosa, Darling
BEST
Brisbane Lions: Hanley, Leuenberger, Rockliff, Moloney, Raines, Clarke
West Coast: Priddis, MacKenzie, Selwood, Kennedy, Glass, Naitanui, Hurn
INJURIES
Brisbane Lions: None
West Coast: None
SUBSTITUTES
Brisbane Lions: Simon Black on for Ryan Lester in the third quarter
West Coast: Bradd Dalziell on for Mitchell Brown in the fourth quarter
Reports: Nil
Umpires: Bannister, Leppard and Schmitt
Crowd: 17,615
