Josh Drummond and James Hawksley return to the side to replace Matt Maguire (foot) and Elliot Yeo (omitted).
Maguire injured his foot during the first quarter of last Saturday night’s match against Adelaide at the Gabba and has been ruled out for the remaining two Lions matches for 2012.
The void left by Maguire is most likely to be filled by Drummond who has been recalled after spending the past two matches on the sidelines, while Hawksley has been named to play just his third senior match for 2012.
Andrew Raines will also line up for his 100th senior AFL match this weekend - 44 of which have been played with the Lions since he was traded from Richmond at the end of 2009.
Read the full preview of Saturday afternoon's match against Port Adelaide
The Lions’ full team for Round 22 is as follows:
B: Ryan Harwood (2), Daniel Merrett (21), Ryan Lester (35)
HB: Pearce Hanley (11), Joel Patfull (24), Jed Adcock (7)
C: Rohan Bewick (43), Daniel Rich (10), James Polkinghorne (31)
HF: Jack Redden (30), Jonathan Brown (16), Dayne Zorko (15)
F: Tom Rockliff (38), Jordan Lisle (19), Josh Green (6)
FOLL: Ben Hudson (22), Simon Black (20), Andrew Raines (29)
INT: James Hawksley (12), Claye Beams (17), Josh Drummond (39), Jack Crisp (47)
EMER: Sam Docherty (1), Billy Longer (5), Elliot Yeo (26)
IN: Hawksley, Drummond
OUT: Maguire (foot), Yeo (omitted)
MILESTONES: Andrew Raines - 100 games
