Brisbane have named a near full-strength squad ahead of their blockbuster clash against Sydney on Sunday.

The Lions will be without exciting first-year forward Kai Lohmann after he suffered an ankle injury last week.

Lohmann will be sidelined for six weeks after scans revealed a high ankle sprain, with the 18-year-old undergoing surgery this week.

Jaxon Prior will come into the side after being activated as medical sub last week.

Sunday's clash looms as one of the biggest of the year with both teams sitting at 5-1 after the opening six rounds.

Speaking on the match, Marcus Adams said it was a challenge the Lions would attack head on.

"Sydney's tough to beat down there. We haven't won at the SCG since 2009, it's a big challenge but one we're looking forward to," Adams said.

Deven Robertson, Nakia Cockatoo, Tom Fullarton and James Madden have been named as emergencies.

Mitch Robinson will return through the VFL after a calf complaint ruled him out of last weeks QClash.