Premiership duo Darcy Fort and Conor McKenna come into the line up along with midfielder James Tunstill.
Two of the changes are forced with the Lions needing to replace midfielder Jarrod Berry (calf) and defender Noah Answerth (concussion) due to injury.
While emerging ruck Zane Zakostelsky returns to the VFL.
The Lions’ interchange is Kai Lohmann, Logan Morris, Conor McKenna, James Tunstill and Bruce Reville.
With Zakostelsky, Shadeau Brain and Darragh Joyce listed as the three emergencies.
Sunday’s match at the Gabba is scheduled to start at 3:15pm, which will be broadcast live on Seven, Fox Footy and Kayo.